6-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮合成路线 （共 4 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6444668 B1, 2002 ;
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: tetrahydrofuran; hexane / -78 - 20 °C 1.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C 2.1: sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
1.1: 100 percent / tetrahydrofuran / 50 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C 3.1: sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
