1,4-二氧杂螺[4.5]癸烷-8-甲胺合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 2 h; Heating;
参考文献
Masic, Lucija P.; Kikelj, Danijel
Tetrahedron Letters, 2000 , vol. 41, # 29 p. 5589 - 5592
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Black
Synthesis, 1981 , vol. No.10, p. 829 - 831
反应条件
1: Et3N / CH2Cl2 / 0 °C 2: NaN3 / dimethylformamide / Heating 3: 22 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164
反应条件
1: superhydride / tetrahydrofuran / -78 - 0 °C 2: Et3N / CH2Cl2 / 0 °C 3: NaN3 / dimethylformamide / Heating 4: 22 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164
反应条件
1: 85 percent / pTSA / benzene / Heating 2: superhydride / tetrahydrofuran / -78 - 0 °C 3: Et3N / CH2Cl2 / 0 °C 4: NaN3 / dimethylformamide / Heating 5: 22 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164
反应条件
1: NaN3 / dimethylformamide / Heating 2: 22 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Levesque, Sophie; St-Denis, Yves; Bachand, Benoit; Preville, Patrice; Leblond, Lorraine; Winocour, Peter D; Edmunds, Jeremy J; Rubin; Siddiqui
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3161 - 3164
反应条件
1: 72 percent / potassium tert-butoxide / 1,2-dimethoxy-ethane; ethanol / 3 h / 0 - 20 °C 2: 77 percent / lithium aluminum hydride / tetrahydrofuran / Heating View Scheme
参考文献
Becker; Flynn
Synthesis, 1992 , # 11 p. 1080 - 1082
反应条件
1: 80 percent / NH4OH / 24 h / Ambient temperature 2: 74 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Black
Synthesis, 1981 , vol. No.10, p. 829 - 831
反应条件
sulfuric acid in ethanol; water 24 h; Heating;
参考文献
Black
Synthesis, 1981 , vol. No.10, p. 829 - 831
反应条件
1: 80 percent / 1 h / 20 °C 2: 77 percent / 90 percent formic acid / 16 h / 20 °C View Scheme
参考文献
Masic, Lucija P.; Kikelj, Danijel
Tetrahedron Letters, 2000 , vol. 41, # 29 p. 5589 - 5592
