2-甲基-4-硝基苯甲酰氯合成路线 （共 11 条）
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
in dichloromethane T=0°C; 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
Location in patent: Paragraph 00146; 00147 ;
反应条件
triethylamine in dichloromethane T=20°C; Acylation; 2 h;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C 2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Maruthi Janakiram; Krishna, Bandi Vamsi
Patent: US2013/190490 A1, 2013 ;
反应条件
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C 2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C 3: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Maruthi Janakiram; Krishna, Bandi Vamsi
Patent: US2013/190490 A1, 2013 ;
反应条件
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C 2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C 3: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 4: 30 percent / NaBH4 / methanol / 1 h / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Maruthi Janakiram; Krishna, Bandi Vamsi
Patent: US2013/190490 A1, 2013 ;
反应条件
1: palladium on carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr
2: iodine cloride; calcium carbonate / water / 24 h / 20 °C
View Scheme
参考文献
Vogrig, Alexandre; Boucherle, Benjamin; Deokar, Hemantkumar; Thomas, Isabelle; Ripoche, Isabelle; Lian, Lu-Yun; Ducki, Sylvie
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3349 - 3353
反应条件
palladium on carbon; hydrogen in methanol
T=20°C; P=760.051 Torr; 24 h;
参考文献
Vogrig, Alexandre; Boucherle, Benjamin; Deokar, Hemantkumar; Thomas, Isabelle; Ripoche, Isabelle; Lian, Lu-Yun; Ducki, Sylvie
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3349 - 3353
反应条件
1: dichloromethane / 0.5 h / 0 °C
2: N,N-dimethyl-formamide / 3 h / 143 °C
3: ammonia / ethylene glycol / 0.5 h / 140 °C / |Microwave irradiation
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
反应条件
1: diethyl ether
2: Ag2O
View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
