2-(1-乙氧基亚乙基)丙二酸二乙酯合成路线

参考文献

Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363

570-08-1乙酰基丙二酸二乙酯+

78-39-7原乙酸三乙酯

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96153 A1, 2013 ;
Location in patent: Page/Page column 162 ;

64-67-5硫酸二乙酯+

570-08-1乙酰基丙二酸二乙酯

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

Suzuki, Naoyuki; Shiota, Takeshi; Watanabe, Fumihiko; Haga, Norihiro; Murashi, Takami; Ohara, Takafumi; Matsuo, Kenji; Oomori, Naoki; Yari, Hiroshi; Dohi, Keiji; Inoue, Makiko; Iguchi, Motofumi; Sentou, Jyunko; Wada, Tooru
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1601 - 1606

2678-54-81,1-二乙氧基乙烯+

105-53-3丙二酸二乙酯

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

McElvain; Burkett
Journal of the American Chemical Society, 1942 , vol. 64, p. 1833
Full Text Show Details
Barnes; Kundiger; McElvain
Journal of the American Chemical Society, 1940 , vol. 62, p. 1285
Full Text Show Details
McElvain; Burkett
Patent: US2394195 , 1942 ;

105-53-3丙二酸二乙酯

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

McElvain; Burkett
Journal of the American Chemical Society, 1942 , vol. 64, p. 1833

854838-42-9+

141-52-6乙醇钠

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

McElvain; Burkett
Journal of the American Chemical Society, 1942 , vol. 64, p. 1833

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

McElvain; Burkett
Journal of the American Chemical Society, 1942 , vol. 64, p. 1833
Full Text Show Details
Barnes; Kundiger; McElvain
Journal of the American Chemical Society, 1940 , vol. 62, p. 1285
Full Text Show Details
McElvain; Burkett
Patent: US2394195 , 1942 ;

108-24-7乙酸酐+

78-39-7原乙酸三乙酯+

105-53-3丙二酸二乙酯

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

参考文献

Sah
Journal of the American Chemical Society, 1931 , vol. 53, p. 1837

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

570-08-1乙酰基丙二酸二乙酯

参考文献

Barnes; Kundiger; McElvain
Journal of the American Chemical Society, 1940 , vol. 62, p. 1285

7647-01-0盐酸+

3044-06-22-(1-乙氧基亚乙基)丙二酸二乙酯

570-08-1乙酰基丙二酸二乙酯

参考文献

Barnes; Kundiger; McElvain
Journal of the American Chemical Society, 1940 , vol. 62, p. 1285