Grubb's 2nd generation catalyst; CuCl2·2H2O; oxygen in 1,2-dichloro-ethane T=60°C; 24 h; Reagent/catalyst;

RuCl2(tricyclohexylphosphine)2(benzylidene); FeCl3·6H2O; oxygen in dichloromethane T=40°C; Grubbs Olefin Metathesis; 24 h; Reagent/catalyst;

1: Fe; AcOH / ethanol / 4 h / 110 °C 2: 35 percent / toluene / 2 h / 110 °C 3: 95 percent / NEt3 / dimethylformamide / 4 h 4: 76 percent / Na2CO3 / PdCl2(dppf) / dimethylformamide; H2O / 1 h / 100 °C 5: 63 percent / 1,3-dimethylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 12 h / 65 °C View Scheme