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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-噻吩乙胺
合成路线
（共 63 条）
30433-91-1
2-噻吩乙胺
→
反应条件
102997-00-2
反应条件
1: 85 percent / K2CO3 / H2O; CHCl3 / 4 h / Ambient temperature 2: 95 percent / K2CO3 / dimethylformamide / 4 h / 90 °C 3: 90 percent / 2N aq. NaOH / ethanol / Ambient temperature; overnight 4: PCl5 / 1,2-dichloro-ethane / 0.5 h / 60 °C 5: SnCl2 / 1,2-dichloro-ethane / 2 h / -10 °C 6: 85 percent / NaBH4 / ethanol / 1 h / Ambient temperature 7: pyrene, 0.1M tetrabutylammonium perchlorate / dimethylformamide / 0.5 h / cathode-mercury electrode, anode-graphite electrode; separation by membrane, ref. electrode-Ag/0.1M AgNO3, appl. pot.=-2.52 V View Scheme
参考文献
Frehel; Badorc; Pereillo; Maffrand
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1011 - 1016
30433-91-1
2-噻吩乙胺
→
反应条件
102997-01-3
5,6,7,8-四氢-4H-噻吩并[2,3-d]氮杂
反应条件
1: 85 percent / K2CO3 / H2O; CHCl3 / 4 h / Ambient temperature 2: 95 percent / K2CO3 / dimethylformamide / 4 h / 90 °C 3: 90 percent / 2N aq. NaOH / ethanol / Ambient temperature; overnight 4: PCl5 / 1,2-dichloro-ethane / 0.5 h / 60 °C 5: SnCl2 / 1,2-dichloro-ethane / 2 h / -10 °C 6: 85 percent / NaBH4 / ethanol / 1 h / Ambient temperature 7: pyrene, 0.1M tetrabutylammonium perchlorate / dimethylformamide / 0.5 h / cathode-mercury electrode, anode-graphite electrode; separation by membrane, ref. electrode-Ag/0.1M AgNO3, appl. pot.=-2.52 V 8: SnCl2*2H2O, 12 N HCl / acetic acid / 2 h / 65 °C View Scheme
参考文献
Frehel; Badorc; Pereillo; Maffrand
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1011 - 1016
30433-91-1
2-噻吩乙胺
→
反应条件
109904-25-8
N-三苯甲基-4,5,6,7-四氢噻吩并[3,2-c]吡啶
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
30433-91-1
2-噻吩乙胺
→
反应条件
109904-26-9
5,6,7,7a-四氢-5-(三苯甲基)噻吩并[3,2-c]吡啶酮
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
30433-91-1
2-噻吩乙胺
+
79-04-9
一氯代乙酰氯
→
反应条件
135709-69-2
2-氯-N-(2-噻吩-2-乙基)乙酰胺
反应条件
potassium carbonate in dichloromethane Ambient temperature;
参考文献
Vecchietti; Clarke; Colle; Giardina; Petrone; Sbacchi
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2624 - 2633
30433-91-1
2-噻吩乙胺
+
50-00-0
甲醛
→
反应条件
111954-31-5
2-噻吩乙基亚甲胺
反应条件
in water Heating;
参考文献
Kitabatake, Michikazu; Hashimoto, Aki; Saitoh, Toshiaki; Sano, Takehiro; Mohri, Kunihiko; Horiguchi, Yoshie
Heterocycles, 2010 , vol. 81, # 8 p. 1903 - 1921
30433-91-1
2-噻吩乙胺
→
反应条件
150322-43-3
普拉格雷
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: tetrahydrofuran / 25 °C 5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 6.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 7.1: hydrogenchloride; water / ethyl acetate / 20 °C 8.1: acetic acid / toluene / 20 °C / Inert atmosphere View Scheme
参考文献
WO2012/1486 A1, ;
30433-91-1
2-噻吩乙胺
→
反应条件
150322-38-6
5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-5,6,7,7a-四氢噻吩并[3,2-c]吡啶-2(4H)-酮
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: tetrahydrofuran / 25 °C 5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 6.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 7.1: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
30433-91-1
2-噻吩乙胺
→
反应条件
115473-15-9
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
30433-91-1
2-噻吩乙胺
+
50-00-0
甲醛
→
反应条件
28783-41-7
反应条件
1: in dichloromethane T=40 - 45°C; 2: With hydrogenchloride in dichloromethane; water; N,N-dimethyl-formamide T=20 - 70°C;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 18 ;
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