(3Ar,6ar)-6-((叔丁基二苯基甲硅烷基氧基)甲基)-2,2-二甲基-3ah-环戊并[d][1,3]二氧代l-4(6ah)-酮合成路线 （共 12 条）
反应条件
dipyridinium dichromate; 4 A molecular sieve in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
Michel, Benoit Y.; Strazewski, Peter
Chemistry - A European Journal, 2009 , vol. 15, # 25 p. 6244 - 6257
反应条件
1.1: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C 1.2: 86 percent / tetrahydrofuran / 7 h / 0 - 20 °C 2.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C 3.1: 96 percent / tetrahydrofuran / 1 h / -78 °C 4.1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 5.1: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Choi, Won Jun; Moon, Hyung Ryong; Kim, Hea Ok; Yoo, Byul Nae; Lee, Jeong A.; Shin, Dae Hong; Jeong, Lak Shin
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2634 - 2636
反应条件
1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C 2: 96 percent / tetrahydrofuran / 1 h / -78 °C 3: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 4: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Choi, Won Jun; Moon, Hyung Ryong; Kim, Hea Ok; Yoo, Byul Nae; Lee, Jeong A.; Shin, Dae Hong; Jeong, Lak Shin
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2634 - 2636
反应条件
1: 96 percent / tetrahydrofuran / 1 h / -78 °C 2: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 3: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Choi, Won Jun; Moon, Hyung Ryong; Kim, Hea Ok; Yoo, Byul Nae; Lee, Jeong A.; Shin, Dae Hong; Jeong, Lak Shin
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2634 - 2636
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide T=20°C; 12 h; Molecular sieve;
参考文献
Deng, Lisheng; Zhang, Li; Yao, Yuan; Wang, Cong; Redell, Michele S.; Dong, Shuo; Song, Yongcheng
MedChemComm, 2013 , vol. 4, # 5 p. 822 - 826
反应条件
1.1: 100 percent / triethylamine; DMAP / CH2Cl2 / 3 h / 20 °C 2.1: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C 2.2: 86 percent / tetrahydrofuran / 7 h / 0 - 20 °C 3.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C 4.1: 96 percent / tetrahydrofuran / 1 h / -78 °C 5.1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 6.1: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Deng, Lisheng; Zhang, Li; Yao, Yuan; Wang, Cong; Redell, Michele S.; Dong, Shuo; Song, Yongcheng
MedChemComm, 2013 , vol. 4, # 5 p. 822 - 826
反应条件
1.1: 100 percent / triethylamine; DMAP / CH2Cl2 / 3 h / 20 °C 2.1: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C 2.2: 86 percent / tetrahydrofuran / 7 h / 0 - 20 °C 3.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C 4.1: 96 percent / tetrahydrofuran / 1 h / -78 °C 5.1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 6.1: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Choi, Won Jun; Moon, Hyung Ryong; Kim, Hea Ok; Yoo, Byul Nae; Lee, Jeong A.; Shin, Dae Hong; Jeong, Lak Shin
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2634 - 2636
反应条件
1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 2: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Choi, Won Jun; Moon, Hyung Ryong; Kim, Hea Ok; Yoo, Byul Nae; Lee, Jeong A.; Shin, Dae Hong; Jeong, Lak Shin
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2634 - 2636
反应条件
1.1: 88 percent / H2SO4 / 3 h / 20 °C 2.1: 100 percent / triethylamine; DMAP / CH2Cl2 / 3 h / 20 °C 3.1: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C 3.2: 86 percent / tetrahydrofuran / 7 h / 0 - 20 °C 4.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C 5.1: 96 percent / tetrahydrofuran / 1 h / -78 °C 6.1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C 7.1: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Michel, Benoit Y.; Strazewski, Peter
Tetrahedron, 2007 , vol. 63, # 39 p. 9836 - 9841
反应条件
1: 95 percent / Grubbs catalyst / CH2Cl2 / 20 °C 2: 84 percent / molecular sieves; PDC / dimethylformamide / 20 °C View Scheme
参考文献
Deng, Lisheng; Zhang, Li; Yao, Yuan; Wang, Cong; Redell, Michele S.; Dong, Shuo; Song, Yongcheng
MedChemComm, 2013 , vol. 4, # 5 p. 822 - 826
