5-羟基-3,4-二氢-2-喹啉酮合成路线 （共 10 条）
反应条件
1: With AlCl3, aluminium chloride T=155 - 165°C; 4 h; 2: With methanol; sodium hydroxide in water T=20°C; pH=7; 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Davidi, Guy; Klopfer, Eyal; Arad, Oded; Kaspi, Joseph
Patent: US2006/79690 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
palladium on activated charcoal in decalin 3 h; Heating;
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Kashimura, Shigenori
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3719
反应条件
hydrogen bromide in water T=130°C; 2.5 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 23 p. 7092 - 7096
反应条件
1: 1.) morpholine, 2.) conc. HCl / 1.) reflux, 16 h, 2.) 15 min 2: conc. HCl / CHCl3 View Scheme
参考文献
Bodor, Nicholas; ElKoussi, Alaaeldin; Kano, Masanobu; Nakamura, Toshio
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 100 - 106
反应条件
morpholine; hydrogenchloride 1.) reflux, 16 h, 2.) 15 min; Yield given. Multistep reaction;
参考文献
Bodor, Nicholas; ElKoussi, Alaaeldin; Kano, Masanobu; Nakamura, Toshio
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 100 - 106
反应条件
potassium hydroxide in N-methyl-acetamide; methanol; benzene
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4317820 A1, 1982 ;
反应条件
potassium hydroxide in N-methyl-acetamide; methanol; benzene
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4416884 A1, 1983 ;
反应条件
sodium hydroxide in methanol
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4482560 A1, 1984 ;
反应条件
sodium hydroxide in water
参考文献
OtsukaPharmaceutical Co., Ltd.
Patent: US4256890 A1, 1981 ;
US 4256890 A
参考文献
OtsukaPharmaceutical Co., Ltd.
Patent: US4256890 A1, 1981 ;
US 4256890 A
