(R)-1-苄基-beta-脯氨醇合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=-30°C; Reduction;
参考文献
Einsiedel, Juergen; Thomas, Christoph; Huebner, Harald; Gmeiner, Peter
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2041 - 2044
反应条件
1: With borane-THF in tetrahydrofuran T=-10 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; methanol 1 h; Heating;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 2.1: BH3-THF / tetrahydrofuran / -10 - 20 °C 2.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: 85 percent / methanol / 12 h / 20 °C 2.1: α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 3.1: BH3-THF / tetrahydrofuran / -10 - 20 °C 3.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: 85 percent / methanol / 12 h / 20 °C 2.1: α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 3.1: BH3-THF / tetrahydrofuran / -10 - 20 °C 3.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1: conc. HCl / 0.5 h / Heating 2: SOCl2 / 16 h / -50 - 20 °C 3: LiAlH4 / diethyl ether / -30 °C View Scheme
参考文献
Einsiedel, Juergen; Thomas, Christoph; Huebner, Harald; Gmeiner, Peter
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2041 - 2044
