1-(4-氯二苯甲基)哌嗪合成路线 （共 25 条）
参考文献
Yakugaku Zasshi, , vol. 74, p. 1049
Chem.Abstr., , p. 11666
反应条件
in ethyl acetate T=20 - 60°C; 12 h; Purification / work up;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2009/78627 A2, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: N-[(4-chlorophenyl)phenylmethyl]piperazine With sodium hydroxide in tetrahydrofuran; water 0.25 h; 2: Ph-CH=CH-CH2Br in tetrahydrofuran; water T=20 - 70°C; 2 h;
参考文献
Venkat Narsaiah; Narsimha
Medicinal Chemistry Research, 2012 , vol. 21, # 4 p. 538 - 541
反应条件
sodium hydroxide in tetrahydrofuran; water T=60 - 70°C; 2 h;
参考文献
Venkat Narsaiah; Narsimha
Medicinal Chemistry Research, 2012 , vol. 21, # 4 p. 538 - 541
反应条件
1: N-[(4-chlorophenyl)phenylmethyl]piperazine With tetrabutylammomium bromide; potassium carbonate in water T=25°C; 2: 2-(2-chloroethoxy)acetamide in water T=80°C;
参考文献
US2011/172425 A1, ;
Page/Page column 8 ;
反应条件
potassium iodide; sodium chloride; sodium carbonate in para-xylene; water; toluene
参考文献
Chemagis Ltd.
Patent: EP952153 A2, 1999 ;
反应条件
ammonium hydroxide; sodium hydroxide; sodium carbonate in N-methyl-acetamide; hydrogenchloride; acetone
参考文献
Salsbury Chemicals, Inc.
Patent: US6239277 B1, 2001 ;
反应条件
1: N-[(4-chlorophenyl)phenylmethyl]piperazine With tetrabutylammomium bromide; potassium carbonate in water T=25°C; 2: 2-(2-hydroxyethoxy)ethyl chloride in water T=80°C; 5 h; 3: With hydrogenchloride
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD.
Patent: US2011/172425 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
sodium hydroxide in hexane; ethyl acetate; toluene
参考文献
American Cyanamid Company
Patent: US4963552 A1, 1990 ;
