1-(4-氯二苯甲基)哌嗪合成路线 （共 25 条）
反应条件
K2CO3; Ki in dichloromethane; butanone
参考文献
NeuroMed Technologies Inc.
Patent: US2005/227999 A1, 2005 ;
反应条件
sodium hydroxide; sodium chloride; hydrogen bromide in hexane; water; acetic acid; toluene
参考文献
U C B, S.A.
Patent: US5478941 A1, 1995 ;
反应条件
hydrogenchloride; zinc in tetrahydrofuran; methanol T=5 - 20°C; 1 h;
参考文献
WO2007/66163 A2, ;
Page/Page column 34-35 ;
WO 2007/066163 A2
反应条件
acetic acid; zinc in methanol 1 h;
参考文献
WO2007/66163 A2, ;
Page/Page column 38-39 ;
WO 2007/066163 A2
反应条件
1: SOCl2 / CH2Cl2 / 1 h / 0 °C 2: acetonitrile / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2519 - 2525
反应条件
sodium hydroxide; water in isopropyl alcohol T=90°C; 2 - 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 5-6 ;
反应条件
sodium hydroxide; water in isopropyl alcohol T=90°C; 48 h; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 8 ;
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 3: acetonitrile / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1822 - 1826
反应条件
potassium hydroxide in methanol 24 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 23 p. 7258 - 7273
反应条件
1: tetrahydrofuran / 1 h / 20 °C 2: SOCl2 / CH2Cl2 / 1 h / 0 °C 3: acetonitrile / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2519 - 2525
