(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮合成路线 （共 6 条）
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮
反应条件
Lindlar's catalyst; ethanol Hydrogenation;
参考文献
Gelbart,A.; Thomas,R.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 284 - 288
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮+
反应条件
sodium hydroxide; 1-imidazolylsulfonylimidazolide; dihydrogen peroxide in tert-butyl alcohol 3 h;
参考文献
Kluge; Schulz; Liebsch
Tetrahedron, 1996 , vol. 52, # 8 p. 2957 - 2976
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮
反应条件
methanol; potassium hydroxide; palladium on activated charcoal Hydrogenation;
参考文献
Upjohn Co.
Patent: US2817670 , 1952 ;
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮+
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Upjohn Co.
Patent: US2817670 , 1952 ;
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮
反应条件
recombinant Digitalis lanata progesterone 5β-reductase 0.5 h; Enzyme kinetics;
参考文献
Herl, Vanessa; Fischer, Gabriele; Mueller-Uri, Frieder; Kreis, Wolfgang
Phytochemistry, 2006 , vol. 67, # 3 p. 225 - 231
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮
→
反应条件
ethanol; nickel Hydrogenation;
参考文献
Pfizer and Co.
Patent: US2708651 , 1955 ;
