2-N-BOC-氨基噻唑-5-羧酸合成路线 （共 6 条）
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 2: With hydrogenchloride in water pH=~ 1 - 2;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/100171 A1, 2009 ;
Location in patent: Page/Page column 109 ;
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol T=60°C; 16 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=1 - 2;
参考文献
WO2011/115758 A1, ;
Page/Page column 8 ;
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=0 - 25°C; 24 h; Industry scale; 2: With acetic acid in tetrahydrofuran; water T=0 - 5°C; pH=4.9; 1 h; Industry scale;
参考文献
WO2012/51450 A1, ;
Page/Page column 27 ;
WO 2012/051450 A1
反应条件
lithium hydroxide; sodium hydroxide in 1,4-dioxane; water; ethyl acetate
参考文献
US2003/119811 A1, ;
US 20030119811 A1
反应条件
1: 4-dimethylaminopyridine / tetrahydrofuran / 18 h 2: aq. KOH / tetrahydrofuran; ethanol / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6819 - 6832
反应条件
Selectfluorreg;; K3PO4 in 2-methyl tetrahydrofuran; water
T=2 - 20°C; 3 h;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 14 ;
