2-(叔丁氧酰胺)噻唑-5-甲酸乙酯合成路线 （共 7 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=30°C; 5.5 h;
参考文献
WO2011/59839 A1, ;
Page/Page column 67-68 ;
WO 2011/059839 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethanolamine in tetrahydrofuran
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane 15 h;
参考文献
US2011/166124 A1, ;
Page/Page column 41 ;
参考文献
US2004/54186 A1, ;
Page 22 ;
US 20040054186 A1
反应条件
1: diisobutylaluminium hydride / dichloromethane / 15 h / -78 - 20 °C 2: manganese(IV) oxide / dichloromethane; ethyl acetate / 14 h / 20 °C View Scheme
参考文献
McCormick, Kevin D.; Aslanian, Robert G.; Mangiaracina, Pietro; Berlin, Michael Y.; De Lera Ruiz, Manuel; Boyce, Christopher W.; Chao, Jianhua; Ting, Pauline C.; Zheng, Junying; Rosenblum, Stuart B.
Patent: US2011/166124 A1, 2011 ;
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 2: With hydrogenchloride in water pH=~ 1 - 2;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/100171 A1, 2009 ;
Location in patent: Page/Page column 109 ;
反应条件
lithium triethylborohydride in tetrahydrofuran T=-45 - 20°C; 23 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
Location in patent: Page/Page column 68 ;
WO 2011/059839 A1
