2-[(3-氯苯基)甲基]-3-氧代丁酸乙酯合成路线 （共 3 条）
反应条件
hydrogen; 10 platinum on carbon in ethyl acetate T=50°C; P=30003 Torr;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENGTSSON, Boel, Ase; BLACKABY, Wesley; CUMMING, John; FAULL, Alan, Wellington; LARSSON, Joakim; NASH, Ian, Alun; OLDHAM, Keith; PAPE, Andrew
Patent: WO2011/114148 A1, 2011 ;
Location in patent: Page/Page column 86-87 ;
WO 2011/114148 A1
反应条件
1: ethyl acetoacetate With sodium ethanolate in ethanol T=20°C; 0.166667 h; 2: 3-chlorophenylmethyl bromide in ethanol 15 h; Reflux;
参考文献
Guezel, Oezlen; Innocenti, Alessio; Scozzafava, Andrea; Salman, Aydin; Parkkila, Seppo; Hilvo, Mika; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 20 p. 9113 - 9120
反应条件
1: piperidine; acetic acid / toluene / 20 - 120 °C 2: hydrogen / 10 platinum on carbon / ethyl acetate / 50 °C / 30003 Torr View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENGTSSON, Boel, Ase; BLACKABY, Wesley; CUMMING, John; FAULL, Alan, Wellington; LARSSON, Joakim; NASH, Ian, Alun; OLDHAM, Keith; PAPE, Andrew
Patent: WO2011/114148 A1, 2011 ;
WO 2011/114148 A1
