3-氧代-雄甾-4-烯-17beta-羧酸合成路线 （共 38 条）
反应条件
1: With sodium hydroxide in water; tert-butyl alcohol T=25°C; 1.16667 h; 2: With sodium hypobromide in water; tert-butyl alcohol T=0°C; 4 h; 3: With hydrogenchloride in water T=20°C; pH=3; 2.5 h;
参考文献
LONZA AG
Patent: WO2006/2966 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
sodium periodate in methanol 24 h;
参考文献
Lidstroem, Pelle; Neu, Henrik; Langstroem, Bengt
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 8 p. 695 - 704
反应条件
potassium hydroxide in methanol Hydrolysis; 5 h; Heating;
参考文献
Xia, Peng; Yang, Zheng-Yu; Xia, Yi; Zheng, Yun-Qing; Cosentino, L.Mark; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1907 - 1911
反应条件
Oxonereg;; sodium hydrogencarbonate in water; acetone T=0 - 25°C;
参考文献
Ashford; Grega
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1523 - 1524
反应条件
1: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 2: 100 percent / aq. KOH / methanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1907 - 1911
反应条件
1: I2 / 1.5 h / Heating 2: methanol / 1 h / Heating 3: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 4: 100 percent / aq. KOH / methanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1907 - 1911
反应条件
1: methanol / 1 h / Heating 2: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 3: 100 percent / aq. KOH / methanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1907 - 1911
反应条件
Reaktion ueber mehrere Stufen;
参考文献
Helvetica Chimica Acta, , vol. 25, p. 65,71
Journal of the American Chemical Society, , vol. 67, p. 1728
反应条件
dihydrogen peroxide in methanol 60 h; Ambient temperature;
参考文献
Steroids, , vol. 46, # 1 p. 665 - 676
反应条件
1.1: NaOMe / toluene / 3 h / 35 °C 1.2: 85 percent / aq. HCl / methanol; toluene 2.1: 87 percent / NaHCO3; Oxone / acetone; H2O / 0 - 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 4 p. 1523 - 1524
