1-溴-2-甲基-1-丙烯合成路线 （共 93 条）
反应条件
NiBr2(PPh3)2; triphenylphosphine; zinc in acetonitrile T=20°C; 6 h;
参考文献
Sasaki, Ken; Nakao, Kikuji; Kobayashi, Yoshihiko; Sakai, Mutsuji; Uchino, Norito; et al.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 8 p. 2446 - 2448
参考文献
Kirrmann
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1925 , vol. 181, p. 672
Annales de Chimie (Cachan, France), 1929 , vol. <10>11, p. 243,284
反应条件
tetrabutylammomium bromide; potassium carbonate; palladium diacetate in N,N-dimethyl-formamide T=100°C; 72 h; Further byproducts given;
参考文献
Dyker, Gerald
Journal of Organic Chemistry, 1993 , vol. 58, # 23 p. 6426 - 6428
反应条件
magnesium 1.) THF, 2.) THF, RT; Yield given. Multistep reaction;
参考文献
Barbot, Francis; Poncini, Laurence; Randrianoelina, Benjamin; Miginiac, Philippe
Journal of Chemical Research, Miniprint, 1981 , # 11 p. 4016 - 4035
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane 1 h; Heating;
参考文献
Fischetti, William; Mak, K. Tim; Stakem, F. Gregory; Kim, Jin-Il; Rheingold, Arnold L.; Heck, Richard F.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 948 - 955
反应条件
(i) Mg, ether, (ii) /BRN= 102394/; Multistep reaction;
参考文献
Cuvigny,T.; Normant,H.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962 , vol. 254, p. 316 - 318
反应条件
triphenylphosphine; [palladium(II)(bis(triphenylphosphanyl))dichloride] in toluene mixt. in toluene stirred at 50°C for 5 h; treated (H2O) at room temp.; extd. (benzene); washed with brine; dried (MgSO4); purified by chromy. on silica gel or by distn. (vac.);
参考文献
Takagi, Jun; Takahashi, Kou; Ishiyama, Tatsuo; Miyaura, Norio
Journal of the American Chemical Society, 2002 , vol. 124, # 27 p. 8001 - 8006
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in 1,4-dioxane T=80°C; 1 h; Inert atmosphere;
参考文献
Li, Yanwu; Silamkoti, Arundutt; Kolavi, Gundurao; Mou, Liyuan; Gulati, Shelly; Air, Gillian M.; Brouillette, Wayne J.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4582 - 4589
反应条件
(i) Mg, ether, (ii) /BRN= 102394/; Multistep reaction;
参考文献
Cuvigny,T.; Normant,H.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962 , vol. 254, p. 316 - 318
反应条件
manganese; zinc(II) chloride in tetrahydrofuran 2.5 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2003/82787 A1, 2003 ;
Location in patent: Page/Page column 106 ;
WO 03/082787 A1
