3-氯-4-吗啉基-1,2,5-噻二唑合成路线 （共 9 条）
参考文献
Synthesis, , # 10 p. 1625 - 1628
反应条件
potassium tert-butylate in tert-butyl alcohol T=25°C; 16 h;
参考文献
Weinstock; Mulvey; Tull
Journal of Organic Chemistry, 1976 , vol. 41, # 19 p. 3121 - 3124
反应条件
potassium tert-butylate in tert-butyl alcohol T=25°C; 16 h;
参考文献
Weinstock; Mulvey; Tull
Journal of Organic Chemistry, 1976 , vol. 41, # 19 p. 3121 - 3124
反应条件
1: 75 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 12 h / 25 °C 2: 90 percent / aq. NaOH / methanol / 8 h View Scheme
参考文献
Weinstock; Mulvey; Tull
Journal of Organic Chemistry, 1976 , vol. 41, # 19 p. 3121 - 3124
反应条件
1: 75 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 12 h / 25 °C 2: 90 percent / aq. NaOH / methanol / 8 h 3: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Rosenbaum, Anton I.; Cosner, Casey C.; Mariani, Christopher J.; Maxfield, Frederick R.; Wiest, Olaf; Helquist, Paul
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5281 - 5289
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
McClure,D.E. et al.
Journal of Organic Chemistry, 1979 , vol. 44, p. 1826 - 1831
反应条件
1: potassium hydroxide / water; dimethyl sulfoxide / |Reflux
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
View Scheme
参考文献
Kong, Xu-Dong; Ma, Qian; Zhou, Jiahai; Zeng, Bu-Bing; Xu, Jian-He
Angewandte Chemie - International Edition, 2014 , vol. 53, # 26 p. 6641 - 6644
Angew. Chem., 2014 , p. 6759 - 6762,4
反应条件
potassium tert-butylate in tert-butyl alcohol
T=25°C; 16 h;
参考文献
Weinstock; Mulvey; Tull
Journal of Organic Chemistry, 1976 , vol. 41, # 19 p. 3121 - 3124
