4-(3-乙氧基-3-氧代丙基)哌啶-1-羧酸叔丁酯合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; 3 h;
参考文献
US2003/191316 A1, ;
Page/Page column 33 ;
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 96 h;
参考文献
Grumel, Valerie; Merour, Jean-Yves; Guillaumet, Gerald
Heterocycles, 2001 , vol. 55, # 7 p. 1329 - 1345
反应条件
triethylamine in dichloromethane T=20°C; 5 h;
参考文献
Yamanaka, Toshio; Ohkubo, Mitsuru; Kuroda, Satoru; Nakamura, Hideko; Takahashi, Fumie; Aoki, Toshiaki; Mihara, Kayoko; Seki, Jiro; Kato, Masayuki
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 13 p. 4343 - 4352
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
反应条件
1: NaH / tetrahydrofuran / 0 °C 2: H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 15 - 20 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 88 percent / HCl; H2 / PtO2 / ethanol; dioxane / 5 h / 45 °C 3.1: 81 percent / triethylamine / CH2Cl2 / 5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 13 p. 4343 - 4352
反应条件
1: 88 percent / HCl; H2 / PtO2 / ethanol; dioxane / 5 h / 45 °C 2: 81 percent / triethylamine / CH2Cl2 / 5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 13 p. 4343 - 4352
反应条件
1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.25 h / -60 °C / Inert atmosphere 2: tetrahydrofuran / 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 8 p. 2305 - 2308
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Rossi, Cristina; Porcelloni, Marina; D'Andrea, Piero; Fincham, Christopher I.; Ettorre, Alessandro; Mauro, Sandro; Squarcia, Antonella; Bigioni, Mario; Parlani, Massimo; Nardelli, Federica; Binaschi, Monica; Maggi, Carlo A.; Fattori, Daniela
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2305 - 2308
反应条件
sodium hydroxide in ethanol T=20°C; 12 h;
参考文献
Yamanaka, Toshio; Ohkubo, Mitsuru; Kuroda, Satoru; Nakamura, Hideko; Takahashi, Fumie; Aoki, Toshiaki; Mihara, Kayoko; Seki, Jiro; Kato, Masayuki
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 13 p. 4343 - 4352
