3,4-二氢-3-羟基-2(1h)-喹啉酮合成路线 （共 5 条）
反应条件
hydrogenchloride; zinc
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/113432 A2, 2006 ;
Location in patent: Page/Page column 79; 35 ;
反应条件
platinum on alumina; hydrogen; CD in methanol T=20°C; P=30003 Torr; 3 h; Autoclave;
参考文献
Szollosi, Gyoergy; Makra, Zsolt; Kovacs, Lenke; Fueloep, Ferenc; Bartok, Mihaly
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1623 - 1629
反应条件
hydrogen; platinum(IV) oxide in ethanol T=20°C; Reduction; Cyclization; Reissert indole synthesis; Product distribution; Further Variations:CatalystsSolvents;
参考文献
Suzuki; Gyoutoku; Yokoo; Shinba; Sato; Yamada; Murakami
Synlett, 2000 , # 8 p. 1196 - 1198
反应条件
1: toluene-4-sulfonic acid / |Reflux 2: CD; hydrogen; platinum on alumina / methanol / 3 h / 20 °C / 30003 Torr / |Autoclave View Scheme
参考文献
Szollosi, Gyoergy; Makra, Zsolt; Kovacs, Lenke; Fueloep, Ferenc; Bartok, Mihaly
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1623 - 1629
反应条件
1: glacial acetic acid; concentrated hydrochloric acid 2: zinc; hydrochloric acid View Scheme
参考文献
Heller
Journal fuer Praktische Chemie (Leipzig), 1923 , vol. <2> 106, p. 10
