4-(4-氯苯基)-1,2,3,6-四氢-吡啶合成路线 （共 15 条）
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 5 h;
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: With ammonium chloride in water T=60°C; 3 h; 2: in methanol 3: With hydrogenchloride in water T=100°C; 4 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 61 ;
反应条件
hydrogenchloride; acetic acid 2 h; Heating;
参考文献
Yu; Caldera; McPhee; De Voss; Jones; Burlingame; Kuntz; Craik; Ortiz De Montellano
Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 5846 - 5856
反应条件
sodium hydroxide in water
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 167; 168 ;
反应条件
sodium azide; boron trifluoride diethyl etherate in 1,4-dioxane T=0°C;
参考文献
Harriman; Shao; Luly
Tetrahedron Letters, 2000 , vol. 41, # 46 p. 8853 - 8856
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US6187774 B1, 2001 ;
反应条件
1: HCl; AcOH 2: HCl 3: NaOH View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: Pd(OAc)2 2: HCl 3: NaOH View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: HCl; AcOH 2: HCl 3: NaOH View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: Pd(OAc)2 2: HCl 3: NaOH View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
