反应条件
1: 3,5-dimethyl-isoxazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; Inert atmosphere; 2: oxirane in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: With hydrogenchloride; ammonium chloride in tetrahydrofuran; hexane; water T=18 - 25°C; pH=~ 7;
参考文献
BIORELIX, INC.; COISH, Philip, D., G.; DIXON, Brian, R.; OSTERMAN, David; ARISTOFF, Paul, Adrian; NAVIA, Manuel; SCIAVOLINO, Frank; AVOLA, Stephanie; BABOULAS, Nick; BELLIOTTI, Thomas, R.; BELLO, Angelica; BERMAN, Judd; CHRUSCIEL, Robert, A.; EVANS, Bruce, R.; KAUR, Harpreet; MOON, David; PHAM, Vinh; ROUGHTON, Andrew; WICKENS, Phil; WILSON, Jeffrey
Patent: WO2011/126567 A1, 2011 ;
Location in patent: Page/Page column 168 ;