3,5-二溴-2,4-二甲基吡啶合成路线 （共 7 条）
反应条件
sulfuric acid; bromine T=155 - 175°C; 24 h;
参考文献
Dunn, Allan D.; Guillermic, Sandrine
Zeitschrift fuer Chemie (Stuttgart, Germany), 1988 , vol. 28, # 2 p. 59 - 60
反应条件
phosphorus; hydrogen iodide 16 h; Heating;
参考文献
Blachut, Dariusz; Czarnocki, Zbigniew; Wojtasiewicz, Krystyna
Synthesis, 2006 , # 17 p. 2855 - 2864
反应条件
1: 79 percent / POCl3 / 8 h / 135 °C 2: 83 percent / aq. HI; phosphorus / 16 h / Heating View Scheme
参考文献
Blachut, Dariusz; Czarnocki, Zbigniew; Wojtasiewicz, Krystyna
Synthesis, 2006 , # 17 p. 2855 - 2864
反应条件
1: Br2; acetic acid / 1 h 2: 79 percent / POCl3 / 8 h / 135 °C 3: 83 percent / aq. HI; phosphorus / 16 h / Heating View Scheme
参考文献
Blachut, Dariusz; Czarnocki, Zbigniew; Wojtasiewicz, Krystyna
Synthesis, 2006 , # 17 p. 2855 - 2864
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=75°C; Suzuki-Miyaura cross-coupling reaction; 24 h; Title compound not separated from byproducts.;
参考文献
Blachut, Dariusz; Czarnocki, Zbigniew; Wojtasiewicz, Krystyna
Synthesis, 2006 , # 17 p. 2855 - 2864
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2: With methanol regioselective reaction;
参考文献
Thalhammer, Armin; Mecinovic, Jasmin; Loenarz, Christoph; Tumber, Anthony; Rose, Nathan R.; Heightman, Tom D.; Schofield, Christopher J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 127 - 135
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2: With methanol regioselective reaction;
参考文献
Thalhammer, Armin; Mecinovic, Jasmin; Loenarz, Christoph; Tumber, Anthony; Rose, Nathan R.; Heightman, Tom D.; Schofield, Christopher J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 127 - 135
