2-(1-苄基哌啶-4-基)丙-2-醇合成路线 （共 6 条）
反应条件
1: in tetrahydrofuran T=-78 - 23°C; 2: With water T=23°C;
参考文献
Hu, Essa; Kunz, Roxanne K.; Rumfelt, Shannon; Hitchcock, Stephen A.; Lindstrom, Michelle; Treanor, James; Andrews, Kristin L.; Li, Chun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6938 - 6942,5
反应条件
methyllithium in tetrahydrofuran T=-78 - 20°C;
参考文献
Hu, Essa; Kunz, Roxanne; Chen, Ning; Nixey, Tom; Hitchcock, Stephen
Patent: US2009/62277 A1, 2009 ;
Location in patent: Page/Page column 14 ;
US 20090062277 A1
反应条件
in tetrahydrofuran; diethyl ether T=0°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 48-49 ;
反应条件
in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Moosa, Basem A.; Ali, Shaikh A.
Arkivoc, 2010 , vol. 2010, # 10 p. 132 - 148
反应条件
1: sodium hydride / mineral oil; N,N-dimethyl-formamide 2: tetrahydrofuran View Scheme
参考文献
Hu, Essa; Kunz, Roxanne K.; Rumfelt, Shannon; Hitchcock, Stephen A.; Lindstrom, Michelle; Treanor, James; Andrews, Kristin L.; Li, Chun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6938 - 6942,5
反应条件
palladium on carbon; hydrogen in ethanol T=20°C; P=2585.81 Torr; 3 h; Inert atmosphere;
参考文献
Moosa, Basem A.; Ali, Shaikh A.
Arkivoc, 2010 , vol. 2010, # 10 p. 132 - 148
