N-1-苄基-2-甲基哌嗪合成路线 （共 13 条）
反应条件
1: in butan-1-ol T=0 - 20°C; 14 h; 2: With sodium hydroxide in water; toluene pH=11.2; 3: With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 16; 20-21 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 72 h; Heating;
参考文献
Charles, Elisabeth S.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 752 - 756
反应条件
1: in butan-1-ol T=0 - 8°C; 2 h; 2: With hydrogenchloride in water; toluene T=0°C; pH=1.0; 0.5 h; 3: With sodium hydroxide in water; toluene T=60 - 170°C; pH=11.8; 0.5 h; Product distribution / selectivity;
参考文献
EP1548010 A1, ;
Page/Page column 21 ;
反应条件
1: (S)-(+)-2-Methylpiperazine in water T=15 - 85°C; 7 h; 2: With calcium hydroxide powder in water T=70 - 82°C; 3 h; 3: benzyl chloroformate With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
EP1548010 A1, ;
Page/Page column 22-23 ;
反应条件
1: 60 percent / methanol / 24 h / Heating 2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 752 - 756
反应条件
1: 60 percent / methanol / 24 h / Heating 2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 752 - 756
反应条件
formic acid in water T=80 - 90°C; 8 h;
参考文献
Landriani, L.; Barlocco, D.; Cignarella, G.; Curzu, M. M.; Anania, V.; Desole, M. S.
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 191 - 204
反应条件
1: 75.31 percent / 90percent formic acid / H2O / 8 h / 80 - 90 °C 2: 76.19 percent / hydrogen / 10percent Pd/C / ethanol View Scheme
参考文献
Charles, Elisabeth S.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 752 - 756
反应条件
1: 67 percent / triethylamine / benzene / Heating 2: 70 percent / hydrogen / 10percent Pd-C / acetic acid / 12 h / 1838.8 Torr 3: 63 percent / triethylamine / acetone / Ambient temperature 4: 61 percent / dil. HCl / 24 h / Heating View Scheme
参考文献
Charles, Elisabeth S.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 752 - 756
反应条件
1: 59 percent / formic acid / 10 h / Heating 2: 25 percent / benzene / 48 h / Heating View Scheme
参考文献
Charles, Elisabeth S.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 752 - 756
