4-(2-苯基-1-乙炔)苯甲腈合成路线 （共 64 条）
反应条件
palladium dichloride in chlorobenzene 4 h; Reflux; Overall yield = 93 percent;
参考文献
Xie, Hou-Zhi; Gao, Qi; Liang, Ying; Wang, Heng-Shan; Pan, Ying-Ming
Green Chemistry, 2014 , vol. 16, # 4 p. 2132 - 2135
反应条件
C41H38BFeN3P2; hydrogen in tetrahydrofuran T=20 - 90°C; P=7500.75 Torr; 72 h; Inert atmosphere;
参考文献
Srimani, Dipankar; Diskin-Posner, Yael; Ben-David, Yehoshoa; Milstein, David
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14131 - 14134
Angew. Chem., 2013 , vol. 125, # 52 p. 14381 - 14383
反应条件
1: With FeH(CO)(NO)(PPh3)2; MePh(vinyl)silane; triethylamine in tetrahydrofuran T=60°C; 2: With sodium hydroxide in tetrahydrofuran; methanol T=130°C; 0.166667 h; Inert atmosphereMicrowave irradiation; optical yield given as percent dediastereoselective reaction;
参考文献
Schabel, Tobias; Belger, Christian; Plietker, Bernd
Organic Letters, 2013 , vol. 15, # 11 p. 2858 - 2861
反应条件
1: With FeH(CO)(NO)(PPh3)2; phenyl silane; triethylamine in tetrahydrofuran T=40°C; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; optical yield given as percent dediastereoselective reaction;
参考文献
Belger, Christian; Plietker, Bernd
Chemical Communications, 2012 , vol. 48, # 44 p. 5419 - 5421
反应条件
water; sodium hydroxide in ethanol 4 h; Reflux;
参考文献
Phetrak, Nared; Rukkijakan, Thanya; Sirijaraensre, Jakkapan; Prabpai, Samran; Kongsaeree, Palangpon; Klinchan, Chayada; Chuawong, Pitak
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12703 - 12709
反应条件
1,3-bis-(diphenylphosphino)propane; sodium lauryl sulfate; tris-(m-sulfonatophenyl)phosphine; [RhCl(η2:η2-cycloocta-1,5-diene)]2 T=100°C; 15 h;
参考文献
Fuji, Koji; Morimoto, Tsumoru; Tsutsumi, Ken; Kakiuchi, Kiyomi
Chemical Communications, 2005 , # 26 p. 3295 - 3297
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; Sonogashira Cross-Coupling; 10 h; Inert atmosphereSchlenk technique;
参考文献
Arundhathi, Racha; Damodara, Dandu; Mohan, Kakita Veera; Kantam, Mannepalli Lakshmi; Likhar, Pravin R.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 751 - 756
反应条件
tetrabutyl ammonium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran
T=20°C; Sonogashira-Hagihara coupling; 24 h;
参考文献
Ahmed, Mohamed S. Mohamed; Sekiguchi, Akitoshi; Shimada, Tomohiro; Kawashima, Jun; Mori, Atsunori
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 2 p. 327 - 330
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; sila-Sonogashira reaction; 1 h;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
1: With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; silver(l) oxide; lithium iodide in N,N-dimethyl-formamide
T=80°C; 3 h; Inert atmosphere;
2: Sonogashira coupling;
参考文献
Kim, Hyunseok; Lee, Phil Ho
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 17 p. 2827 - 2832
