4-苄氧基-反-β-硝基苯乙烯合成路线 （共 9 条）
反应条件
1: With sodium methylate in methanol T=0 - 20°C; 0.166667 h; 2: With hydrogenchloride; water in methanol T=0 - 20°C; 0.25 h;
参考文献
MATSUKURA, Masayuki
Patent: US2010/331282 A1, 2010 ;
Location in patent: Page/Page column 8-9 ;
反应条件
ammonium acetate 1 h; RefluxInert atmosphere;
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W.
Patent: WO2010/42998 A1, 2010 ;
Location in patent: Page/Page column 98 ;
WO 2010/042998 A1
反应条件
tert.-butylnitrite; copper(l) chloride in acetonitrile T=80°C;
参考文献
Rokade, Balaji V.; Prabhu, Kandikere Ramaiah
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 39 p. 6713 - 6716
反应条件
in methanol; nitromethane
反应条件
1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 60 °C 2: sodium hydroxide / ethanol; water / 60 °C 3: copper(l) chloride; tert.-butylnitrite / acetonitrile / 80 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 39 p. 6713 - 6716
反应条件
1: sodium hydroxide / ethanol; water / 60 °C 2: copper(l) chloride; tert.-butylnitrite / acetonitrile / 80 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 39 p. 6713 - 6716
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 3 h;
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W.
Patent: WO2010/42998 A1, 2010 ;
Location in patent: Page/Page column 98 ;
WO 2010/042998 A1
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=0°C; P=760 Torr;
参考文献
Kohno; Sasao; Murahashi
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1252 - 1254
反应条件
1: 56 percent / LiAlH4 / tetrahydrofuran
2: 76 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
