4-苄氧基-3-氨基-a-[-苄基-n-(1-甲基-2p-甲氧基苯酯) 氨基甲基苄醇合成路线 （共 10 条）
反应条件
hydrogenchloride in ethyl acetate T=20°C;
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1: With caesium carbonate in N,N-dimethyl-formamide T=50°C; 1.5 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water 16 h;
参考文献
Magnus, Nicholas A.; Astleford, Bret A.; Brennan, John; Stout, James R.; Tharp-Taylor, Roger W.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 280 - 284
反应条件
1: 58 percent / K2CO3 / dimethylformamide / 20 °C 2: 97 percent / HCl / ethyl acetate / 20 °C View Scheme
参考文献
Rigel Pharmaceuticals, Inc.; Goff, Dane; Payan, Donald G.; Braselmann, Sylvia
Patent: US2013/237524 A1, 2013 ;
反应条件
1: 91 percent / aq. NaHCO3 / tetrahydrofuran / 24 h 2: 58 percent / K2CO3 / dimethylformamide / 20 °C 3: 97 percent / HCl / ethyl acetate / 20 °C View Scheme
参考文献
Rigel Pharmaceuticals, Inc.; Goff, Dane; Payan, Donald G.; Braselmann, Sylvia
Patent: US2013/237524 A1, 2013 ;
反应条件
1: 828 mg / potassium carbonate / methanol / Heating 2: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol View Scheme
参考文献
Battersby; Chrystal; Staunton
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 31 - 42
反应条件
1: 310 mg / sodium hydroxide / methanol; H2O / 1 h / 70 °C 2: 828 mg / potassium carbonate / methanol / Heating 3: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol View Scheme
参考文献
Battersby; Chrystal; Staunton
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 31 - 42
反应条件
hydrogenchloride; lithium aluminium tetrahydride 1.) ether, reflux, 1 h, 2.) methanol; Yield given. Multistep reaction;
参考文献
Battersby; Chrystal; Staunton
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 31 - 42
反应条件
sodium hydroxide in diethyl ether; water
参考文献
Rigel Pharmaceuticals, Inc.; Goff, Dane; Payan, Donald G.; Braselmann, Sylvia
Patent: US2013/237524 A1, 2013 ;
Location in patent: Paragraph 0226 ;
反应条件
1: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol 2: 7 mg / NAD+, ethanol, liver alcohol dehydrogenase, pea seedling diamine oxidase, phosphate buffer (pH 8), catalase / 32 h / 37 °C / further catalysts View Scheme
参考文献
Battersby; Chrystal; Staunton
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 31 - 42
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) methanol, 2.) ethanol; Yield given. Multistep reaction;
参考文献
Battersby; Chrystal; Staunton
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 31 - 42
