5,6,7,8-四氢-8-氨基喹啉合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/20415 A1, 2006 ;
Location in patent: Page/Page column 112 ;
WO 2006/020415 A1
反应条件
1: With hydrogen; palladium 10 on activated carbon in methanol P=1551.49 Torr; 2: T=115 - 140°C; P=0.2 Torr;
参考文献
AnorMED, Inc.
Patent: US6750348 B1, 2004 ;
Location in patent: Page column 16 ;
US 6750348 B1
反应条件
ammonium acetate; sodium cyanoborohydride in ethanol T=130°C; 0.0333333 h; Microwave irradiation;
参考文献
Dong, Li; Aleem, Saadat; Fink, Cynthia A.
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5210 - 5212
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
参考文献
Skupinska, Krystyna A.; McEachern, Ernest J.; Baird, Ian R.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3546 - 3551
反应条件
1: 80 percent / HCl / H2O / 2 h / 130 °C 2: 87 percent / 0.5 h / 150 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 9 p. 3546 - 3551
反应条件
1.1: n-BuLi; LDA / hexane; various solvent(s) / -15 °C 1.2: 75 percent / isoamyl nitrite / hexane; various solvent(s) / 1 h / -15 °C 2.1: 84 percent / conc. NH4OH; ammonium acetate; Zn / H2O / 16 h / 50 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3497 - 3502
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 8 p. 3376 - 3388
反应条件
Candida antarctica lipase B in di-isopropyl ether T=60°C; 4 h;
参考文献
Skupinska, Krystyna A.; McEachern, Ernest J.; Baird, Ian R.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3546 - 3551
反应条件
1: immobilized Candida antarctica Lipase B; 5,6,7,8-tetrahydroquinolin-8-one; molecular sieves 4 Angstroem / toluene / 48 h / 50 °C 2: water View Scheme
参考文献
Crawford, Jason B.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 669 - 671
