lithium aluminium tetrahydride in diethyl ether T=0°C; Inert atmosphere;

trifluoroacetic acid in dichloromethane Deacylation;

1: 82 percent / pyridine / dimethylformamide / 60 h / 23 °C 2: trifluoroacetic acid / CH2Cl2 / 23 °C View Scheme

1: 100 percent / CH2Cl2 2: pyridine 3: pyridine 4: TFA / CH2Cl2 View Scheme

1: pyridine 2: pyridine 3: TFA / CH2Cl2 View Scheme

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C 2.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 4 h / Reflux 2.2: 0.5 h View Scheme

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 0 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C 3.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 4 h / Reflux 3.2: 0.5 h View Scheme