1: N-[(4-chlorophenyl)phenylmethyl]piperazine With sodium hydroxide in tetrahydrofuran; water 0.25 h; 2: Ph-CH=CH-CH2Br in tetrahydrofuran; water T=20 - 70°C; 2 h;

1.1: hydrogenchloride; calcium chloride / water / 4 h / 20 °C / Reflux 2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux 3.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h 3.2: 2 h / 20 - 70 °C View Scheme

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux 2.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h 2.2: 2 h / 20 - 70 °C View Scheme

1.1: sodium tetrahydroborate / methanol / 1.25 h / 0 - 20 °C 2.1: hydrogenchloride; calcium chloride / water / 4 h / 20 °C / Reflux 3.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux 4.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h 4.2: 2 h / 20 - 70 °C View Scheme