21-羟基-5Alpha-孕甾(烷)-3,20-二酮合成路线 （共 5 条）
反应条件
potassium hydroxide in methanol T=20°C; Substitution; 2 h;
参考文献
Slavikova, Barbora; Kasal, Alexander; Budesinsky, Milos
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 7 p. 1125 - 1134
参考文献
Pfizer and Co.
Patent: US2708651 , 1955 ;
Full Text Show Details
Djerassi; Nussbaum
Journal of the American Chemical Society, 1953 , vol. 75, p. 3700,3703
反应条件
in ethanol T=24 - 26°C; 96 h; Penicillium decumbens ATCC 10436, potato dextrose broth;
参考文献
Holland, Herbert L.
Steroids, 1995 , vol. 60, # 9 p. 646 - 649
反应条件
2: methanol. HCl; CHCl3 View Scheme
参考文献
Djerassi; Nussbaum
Journal of the American Chemical Society, 1953 , vol. 75, p. 3700,3703
→
303-01-5(5R,8R,9S,10S,13S,14S,17S)-17-(2-羟基乙酰基)-10,13-二甲基-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-3-酮+
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Upjohn Co.
Patent: US2817670 , 1952 ;
