4,4-二甲基-3,4-二氢-2H-萘-1-酮合成路线 （共 37 条）
反应条件
1: 80 percent / AlCl3, Br2 / CH2Cl2 / 70 °C 2: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 3: K2CO3 / methanol 4: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 5: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
sulfuric acid; nitric acid in water T=0 - 10°C;
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Husten, Jean; Lisko, Joseph G.; McHugh, Robert J.; Milkiewicz, Karen L.; Murthy, Seetha; Ott, Gregory R.; Theroff, Jay P.; Tripathy, Rabindranath; Underiner, Ted L.; Zificsak, Craig A.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 164 - 167
参考文献
Allergan
Patent: US5723666 A1, 1998 ;
反应条件
1: 80 percent / AlCl3, Br2 / CH2Cl2 / 70 °C 2: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 3: K2CO3 / methanol 4: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
1: 80 percent / AlCl3, Br2 / CH2Cl2 / 70 °C 2: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 3: K2CO3 / methanol View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
aluminium trichloride; bromine in dichloromethane T=70°C;
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
Title/Abstract Full Text View citing articles Show Details
Johnson, Alan T.; Wang, Liming; Gillett, Samuel J.; Chandraratna, Roshantha A. S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 573 - 576
反应条件
hydrogenchloride; bromine; AlCl3
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol; water
P=3102.9 Torr; 5 h; Ambient temperature;
参考文献
Alvi, Khisal A.; Rodriguez, Jaime; Diaz, Maria Cristina; Moretti, Robert; Wilhelm, Robert S.; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4871 - 4880
反应条件
1: 81 percent / NaH / tetrahydrofuran / 16 h / Heating
2: 81 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, AcOH / tetrahydrofuran / 16 h / Ambient temperature
3: 40 percent / aq. NaOH / 2 h / Heating
View Scheme
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
