(Z)-2-(乙氧基甲基)-3-甲氧基丙烯酸乙酯合成路线 （共 7 条）
反应条件
1: 3-Ethoxy-propionic acid ethyl ester; formic acid ethyl ester With ethanol; sodium in benzene T=0°C; Claisen condensation; 2 h; 2: dimethyl sulfate in benzene T=50°C; 3 h;
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
formic acid ethyl ester; benzene beim Erwaermen des Reaktionsgemisches mit Dimethylsulfat; in dem Praeparat hat ein Gemisch der Stereoisomeren vorgelegen;
参考文献
Takamizawa et al.
Yakugaku Zasshi, 1959 , vol. 79, p. 664,668
Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238,242
Chem.Abstr., 1959 , p. 21975
反应条件
1: 66 percent / aq. HCl / ethanol / Heating 2: Br2; AcOH / 1.5 h / Heating 3: POCl3; N,N-dimethylaniline / 1.5 h / Heating View Scheme
参考文献
Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
反应条件
1: 66 percent / aq. HCl / ethanol / Heating 2: Br2; AcOH / 1.5 h / Heating View Scheme
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
1: 66 percent / aq. HCl / ethanol / Heating 2: Br2; AcOH / 1.5 h / Heating 3: POCl3; N,N-dimethylaniline / 1.5 h / Heating 4: ethanolic NH3 / 1 h / 100 °C View Scheme
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
1: water; hydrogenchloride / ethanol / |Reflux
2: bromine; acetic acid / 1.5 h / |Reflux
3: trichlorophosphate / N,N-dimethyl-aniline; Petroleum ether / 1.5 h / |Reflux
4: N,N-dimethyl-formamide / 1.5 h / 20 °C
View Scheme
参考文献
Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
