5-溴吡啶-2-羧酸甲酯合成路线 （共 27 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine in N,N-dimethyl-formamide T=50°C; P=1551.4 Torr; 6 h;
参考文献
Synthetic Communications, , vol. 27, # 3 p. 515 - 520
反应条件
1: With thionyl chloride T=20°C; 3 h; Reflux; 2: With sodium hydrogencarbonate pH=7;
参考文献
WO2012/76898 A1, ;
Page/Page column 64-65 ;
WO 2012/076898 A1
反应条件
in methanol; benzene T=20°C; 1 h; Inert atmosphere;
参考文献
WO2012/31298 A2, ;
Page/Page column 123-124 ;
WO 2012/031298 A2
反应条件
TEA; bis-triphenylphosphine-palladium(II) chloride T=60°C; P=3102.97 Torr; 15 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 2 p. 605 - 608
反应条件
1.1: n-butyllithium / toluene / 3 h / -77 °C 1.2: toluene 2.1: thionyl chloride / 4 h / Heating 3.1: triethylamine / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 45 p. 10748 - 10756
反应条件
triethylamine T=20°C;
参考文献
Tetrahedron, , vol. 61, # 45 p. 10748 - 10756
反应条件
1: thionyl chloride / 4 h / Heating 2: triethylamine / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 45 p. 10748 - 10756
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 4 p. 1407 - 1412
反应条件
1: sodium tetrahydroborate; ethanol / 0 - 20 °C 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / |Inert atmosphere View Scheme
反应条件
lithium hydroxide; ethanol; water T=20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/95159 A1, 2006 ;
Location in patent: Page/Page column 70-71 ;
WO 2006/095159 A1
