(R)-2-羟基-4-苯基丁酸合成路线 （共 58 条）
反应条件
1: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 2: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 97 percent / cc. H2SO4 / 2 h / Heating 2: 85 percent / CH2Cl2; pyridine / 2 h / 10 °C 3: 10percent aq. Na2CO3 / CH2Cl2 / 5 h / Ambient temperature 4: 91 percent / HCl / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 2: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 3: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 4: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 5: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 2: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 3: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 2: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 3: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 4: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 5: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 6: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
BIS-TRIS buffer; Lactobacillus paracasei DSM 20008; magnesium chloride T=42°C; pH=6.5;
参考文献
Larissegger-Schnell, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Tetrahedron, 2006 , vol. 62, # 12 p. 2912 - 2916
反应条件
hydrogenchloride; TSOH; NADH-H+; sodium formate; pyridinium p-toluenesulfonate in methanol; water; acetone
参考文献
Genzyme Ltd.
Patent: US5686275 A1, 1997 ;
反应条件
Lactobacillus paracasei DSM 20207 in water
T=42°C; pH=6; 24 h; Product distribution; Further Variations:Reagents;
参考文献
Nestl, Bettina M.; Glueck, Silvia M.; Hall, Melanie; Kroutil, Wolfgang; Stuermer, Rainer; Hauer, Bernhard; Faber, Kurt
European Journal of Organic Chemistry, 2006 , # 20 p. 4573 - 4577
