(R)-2-羟基-4-苯基丁酸合成路线 （共 58 条）
反应条件
formic acid; triethylamine; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; (1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine in methanol T=20 - 40°C; 3.5 h;
参考文献
Kaneka Corporation
Patent: EP2053032 A1, 2009 ;
Location in patent: Page/Page column 11-12 ;
反应条件
potassium hydroxide in ethanol 16 h; Ambient temperature;
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
hydrogen; QNM; 5percent Pt/Al2O3 (JMC94) in acetic acid T=25°C; P=37503.8 Torr; 1 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 11 p. 1253 - 1260
反应条件
hydrogen; palladium on activated charcoal in acetic acid Yield given;
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
hydrogen; palladium on activated charcoal in methanol 0.166667 h;
参考文献
Larissegger-Schnell, Barbara; Kroutil, Wolfgang; Faber, Kurt
Synlett, 2005 , # 12 art. no. G12405ST, p. 1936 - 1938
反应条件
potassium carbonate in methanol T=0°C; 5 h;
参考文献
Larissegger-Schnell, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Tetrahedron, 2006 , vol. 62, # 12 p. 2912 - 2916
反应条件
urea; trifluoroacetic acid; sodium nitrite in dichloromethane; sulfuric acid; water
反应条件
Bacillus subtilis; NADPH in aq. phosphate buffer T=30°C; 12 h;
参考文献
Su, Yuning; Ni, Ye; Wang, Junchao; Xu, Zhihao; Sun, Zhihao
Chinese Journal of Catalysis, 2012 , vol. 33, # 9-10 p. 1650 - 1660
反应条件
sodium hydroxide in methanol; water T=20°C; 4 h;
参考文献
Capitta, Francesca; Frongia, Angelo; Piras, Pier Paolo; Pitzanti, Patrizia; Secci, Francesco
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2955 - 2960
反应条件
sulfuric acid; sodium nitrite in acetic acid 24 h, r.t.; 3 h, 100 deg C;
参考文献
Iwasaki; Kimura; Numao; Kondo
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 2 p. 280 - 283
