2-氟-5-甲基苯甲酸甲酯合成路线 （共 9 条）
反应条件
potassium carbonate in acetone Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 218-219 ;
反应条件
thionyl chloride 20 h; Reflux;
参考文献
ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan
Patent: WO2012/125521 A1, 2012 ;
Location in patent: Page/Page column 35; 36 ;
WO 2012/125521 A1
反应条件
thionyl chloride in methanol; ethyl acetate
反应条件
potassium carbonate in acetone Heating;
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4416 - 4420
反应条件
1: 75 percent aq. H2SO4 / 0.5 h / 150 °C 2: aq. HCl / 14 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 22 p. 3217 - 3220
反应条件
1: With N-bromosuccinmide in tetrachloromethane 20 h; Irradiation; 2: With water; silver nitrate in acetone
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
6.5 h; Inert atmosphereReflux;
参考文献
ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan
Patent: WO2012/125521 A1, 2012 ;
Location in patent: Page/Page column 35; 36 ;
WO 2012/125521 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
20 h; Heating;
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
