1,4-苯并二恶烷-6-甲醛合成路线 （共 44 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=70°C; 16 h;
参考文献
UNIBIOSCREEN S.A.
Patent: WO2005/105753 A2, 2005 ;
Location in patent: Page/Page column 63-64 ;
WO 2005/105753 A2
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; potassium formiate; tetra-(n-butyl)ammonium iodide; PCy3∙HBF4; bis(dibenzylideneacetone)-palladium(0); [(t-Bu)3PH]BF4 T=100°C; 18 h; Sealed tubeGloveboxInert atmosphere; Reagent/catalystSolvent;
参考文献
Korsager, Signe; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 6112 - 6120
反应条件
in trifluoroacetic acid T=90 - 95°C; 24 h;
参考文献
Zhilina, Z. I.; Mel'nik, V. I.; Andronati, S. A.; Abramovich, A. E.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 5.2 p. 957 - 963
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 5 p. 1063 - 1070
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 11 p. 1457 - 1461
反应条件
1: 1) AlCl3, 2) 10percent HCl / 1) benzene, temp ,40 deg C, 2) benzene, 1 h, 50 deg C 2: 48percent HBr / 15 h / Ambient temperature 3: 48 percent / NaOMe / methanol / 24 h / Heating View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 38, # 4 p. 265 - 273
反应条件
1: 78 percent / NaOEt / dimethylformamide / 0.5 h / Ambient temperature 2: 1) AlCl3, 2) 10percent HCl / 1) benzene, temp ,40 deg C, 2) benzene, 1 h, 50 deg C 3: 48percent HBr / 15 h / Ambient temperature 4: 48 percent / NaOMe / methanol / 24 h / Heating View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 38, # 4 p. 265 - 273
反应条件
1: 48percent HBr / 15 h / Ambient temperature 2: 48 percent / NaOMe / methanol / 24 h / Heating View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 38, # 4 p. 265 - 273
参考文献
Annales de Chimie (Cachan, France), , vol. <7> 18, p. 130
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 126, p. 1427
Bulletin de la Societe Chimique de France, , vol. <3> 19, p. 508
反应条件
N-bromosuccinmide; n-butyllithium 1) MeOH, 2) THF, -78 deg C; Multistep reaction;
参考文献
Synthetic Communications, , vol. 26, # 9 p. 1729 - 1738
反应条件
hydrogenchloride; aluminium trichloride Zersetzung des Reaktionsprodukts durch Erhitzen mit verd. Salzsaeure;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 357, p. 373
