2-氟-5-硝基苯甲酸甲酯合成路线 （共 12 条）
反应条件
thionyl chloride 24 h; Reflux;
参考文献
Suchaud, Virginie; Bailly, Fabrice; Lion, Cedric; Calmels, Christina; Andreola, Marie-Line; Christ, Frauke; Debyser, Zeger; Cotelle, Philippe
Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4640 - 4660
反应条件
potassium fluoride; PEG 5090 in dimethyl sulfoxide T=115°C; 12 h;
参考文献
Deutsch; Niclas
Synthetic Communications, 1991 , vol. 21, # 4 p. 505 - 513
反应条件
1: 2-fluoro-5-nitro-benzoic acid With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.333333 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere;
参考文献
Lee, Yun J.; King, Jason R.; Chenna, Bala Chandra; Owens Jr., Samuel B.; Freeman, Jason L.; Gray, Gary M.; Velu, Sadanandan E.
Journal of Chemical Crystallography, 2009 , vol. 39, # 12 p. 902 - 907
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Bahmanyar; Borer, Bennett C.; Young, Mi Kim; Kurtz, David M.; Yu, Shu
Organic Letters, 2005 , vol. 7, # 6 p. 1011 - 1014
反应条件
in hydrogenchloride; methanol
参考文献
Eli Lilly and Company
Patent: US6635657 B1, 2003 ;
US 6635657 B1
反应条件
1: H2SO4 / 1,2-dichloro-ethane 2: KF / dimethylformamide / 155 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 49, p. 583 - 587
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 12 p. 1657 - 1661
反应条件
1: nitric acid; sulfuric acid / 2 h / 10 - 25 °C 2: thionyl chloride / 24 h / Reflux View Scheme
参考文献
WO2012/85003 A1, ;
WO 2012/085003 A1
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
hydrogen; palladium on activated charcoal in methanol P=1034.3 - 1551.4 Torr;
参考文献
Soundararajan, N.; Platz, Matthew S.
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2034 - 2044
