反式-4-氧基-2-丁烯酸乙酯合成路线 （共 44 条）
反应条件
potassium carbonate in tetrahydrofuran Yield given;
参考文献
Stambouli, A.; Chastrette, F.; Amouroux, R.; Chastrette, M.; Mattioda, G.; Blanc, A.
Tetrahedron Letters, 1986 , vol. 27, # 35 p. 4149 - 4152
反应条件
hydrogenchloride in ethanol; water T=0 - 20°C;
参考文献
Struble, Justin R.; Bode, Jeffrey W.
Tetrahedron, 2009 , vol. 65, # 26 p. 4957 - 4967
反应条件
calcium chloride 72 h; Ambient temperature;
参考文献
Landor, Stephen R.; Landor, Phyllis, D.; Kalli, Michael
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2921 - 2926
反应条件
sodium hexamethyldisilazane in diethyl ether T=-78°C; Yield given. Yields of byproduct given;
参考文献
Ovanesyan; Garibyan; Badanyan
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 7 p. 951 - 954
反应条件
1: With dihydrogen peroxide in chloroform T=-20°C; 16 h; 2: With N-ethyl-N,N-diisopropylamine in chloroform T=30°C; 15 h; Further stages. Title compound not separated from byproducts.;
参考文献
Zhao, Gui-Ling; Cordova, Armando
Tetrahedron Letters, 2007 , vol. 48, # 34 p. 5976 - 5980
反应条件
1: With dihydrogen peroxide in chloroform T=-20°C; 16 h; 2: With N-ethyl-N,N-diisopropylamine in chloroform T=30°C; 15 h; Further stages. Title compound not separated from byproducts.;
参考文献
Zhao, Gui-Ling; Cordova, Armando
Tetrahedron Letters, 2007 , vol. 48, # 34 p. 5976 - 5980
反应条件
in diethyl ether T=-85°C; 2 h;
参考文献
Son, Sunghee; Fu, Gregory C.
Journal of the American Chemical Society, 2008 , vol. 130, # 9 p. 2756 - 2757
反应条件
in tetrahydrofuran Grignard reaction; 1 h; cooling;
参考文献
Rodriguez, Santiago; Vidal, Alberto; Monroig, Juan J.; Gonzalez, Florenci V.
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5359 - 5361
反应条件
in acetonitrile T=80°C; 6 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/76442 A1, 2003 ;
Location in patent: Page/Page column 53-54 ;
WO 03/076442 A1
反应条件
Pearlman's catalist; hydrogen in ethyl acetate 9 h;
参考文献
Izquierdo, Javier; Rodriguez, Santiago; Gonzalez, Florenci V.
Organic Letters, 2011 , vol. 13, # 15 p. 3856 - 3859
