2-氨基-2',5-二氯二苯酮合成路线 （共 36 条）
反应条件
1: 1) NaNO2/HCl/aq. CH3COOH, 2) aq. KI
2: 27.4 percent / NH2OH*HCl, piperidine / pyridine / 20 h / Heating
3: 83 percent / NaNO2, 1 N HCl / ethanol; H2O / 0.25 h / ice bath
View Scheme
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
反应条件
2: 17 percent / AcOH / ethanol / 6 h / Ambient temperature
4: 99 percent / 30percent HBr, AcOH / acetonitrile / 1.) RT, 1.5 h, 2.) reflux, 1 h
5: 69 percent / dimethylformamide / 3 h / 50 - 60 °C
6: 86.4 percent / NH2NH2*H2O / ethanol / 1 h / Heating
View Scheme
参考文献
Hirai; Fujishita; Ishiba; Sugimoto; Matsutani; Tsukinoki; Hirose
Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1466 - 1473
反应条件
1: 1) acetic acid; 2) N2H4*H2O, acetic acid / 1)benzene, reflux 20 min ; 2)ethanol, room temp.17 h.
2: 59 percent / 5 h / 110 °C
View Scheme
参考文献
Hester Jr.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 3 p. 575 - 581
反应条件
sodium hydroxide; tetrabutylammomium bromide in tetrahydrofuran
T=60°C; 1 h;
参考文献
Mouzin, Gilbert; Cousse, Henri; Autin, Jean-Marie
Synthesis, 1981 , # 6 p. 448 - 449
反应条件
potassium hydroxide in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Hirai, Kentaro; Ishiba, Teruyuki; Fujishita, Toshio; Sugimoto, Hirohiko
Heterocycles, 1980 , vol. 14, # 5 p. 635 - 638
反应条件
1: With triethylsilane; boron trifluoride diethyl etherate in dichloromethane
T=20°C; 90 h; Heating / reflux;
2: With sodium hydroxide in dichloromethane; water
参考文献
SANOFI-AVENTIS
Patent: US2007/185136 A1, 2007 ;
Location in patent: Page/Page column 74 ;
US 20070185136 A1
