2-氨基-2',5-二氯二苯酮合成路线 （共 36 条）
反应条件
in toluene T=10 - 20°C; 3.5 h;
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
1: 1.) HMPA, SOCl2 / 1.) -5 deg C, 20 min, 2.) RT, overnight
2: 78 percent / 24percent HBr / acetic acid / 1.5 h / Ambient temperature
View Scheme
参考文献
Hirai; Ishiba; Sugimoto; Sasakura; Fujishita; Toyoda; Tsukinoki; Joyama; Hatakeyama; Hirose
Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 764 - 773
反应条件
sulfuric acid; potassium iodide; sodium nitrite
1.) 1 h, 2.) room temp., overnight; Yield given. Multistep reaction;
参考文献
Hoffmann-La Roche Inc.
Patent: US4318854 A1, 1982 ;
反应条件
hydrogenchloride; acetic acid; potassium iodide; sodium nitrite
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
反应条件
1: 1.) sodium nitrite, conc. sulfuric acid, 2.) aq. potassium iodide / 1.) 1 h, 2.) room temp., overnight
2: 39 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH2Cl2 / 20 h / Ambient temperature
3: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Trybulski, Eugene J.; Reeder, Earl; Blount, John F.; Walser, Armin; Fryer, R. Ian
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2441 - 2447
反应条件
hydrogenchloride; acetic acid; potassium iodide; sodium nitrite
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
反应条件
1: 1.) sodium nitrite, conc. sulfuric acid, 2.) aq. potassium iodide / 1.) 1 h, 2.) room temp., overnight
2: 39 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH2Cl2 / 20 h / Ambient temperature
3: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature
4: 72 percent / 7 h / Ambient temperature
View Scheme
参考文献
Trybulski, Eugene J.; Reeder, Earl; Blount, John F.; Walser, Armin; Fryer, R. Ian
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2441 - 2447
反应条件
1: 1) NaNO2/HCl/aq. CH3COOH, 2) aq. KI
2: 8.5 percent / Ni(COD)2 / dimethylformamide / 24 h / 40 °C
View Scheme
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
反应条件
1: 1) NaNO2/HCl/aq. CH3COOH, 2) aq. KI
2: 8 percent / NH2OH*HCl / pyridine / 21 h / Heating
View Scheme
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
反应条件
1: 1) NaNO2/HCl/aq. CH3COOH, 2) aq. KI
2: 8 percent / NH2OH*HCl / pyridine / 21 h / Heating
3: 95 percent / Et3N / cuprous iodide, bis(triphenylphosphine)palladium(II)chloride / CH2Cl2 / Heating
View Scheme
参考文献
Coffen; Schaer; Bizzarro; Cheung
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 296 - 300
