2-氨基-2',5-二氯二苯酮合成路线 （共 36 条）
反应条件
iron; acetic acid in ethanol; water T=60 - 70°C; 2 h;
参考文献
Vejdelek; Rajsner; Dlabac; et al.
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 12 p. 3593 - 3615
反应条件
(i) ZnCl2, (ii) aq. HCl, (iii) H2SO4; Multistep reaction;
参考文献
Pharmaceutical Chemistry Journal, , vol. 11, # 11 p. 1520 - 1525
Khimiko-Farmatsevticheskii Zhurnal, , vol. 11, # 11 p. 85 - 91
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 1.25 h / -40 °C / Inert atmosphere 2.1: hydrogenchloride; water / ethanol / Reflux 2.2: pH 8 View Scheme
参考文献
Molecules, , vol. 16, # 9 p. 7649 - 7661
反应条件
1.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C 2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1.25 h / -40 °C / Inert atmosphere 3.1: hydrogenchloride; water / ethanol / Reflux 3.2: pH 8 View Scheme
参考文献
Molecules, , vol. 16, # 9 p. 7649 - 7661
反应条件
1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 45, # 12 p. 3593 - 3615
反应条件
1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 45, # 12 p. 3593 - 3615
反应条件
1.1: SOCl2 / Heating 2.1: ZnCl2 / 2 h / 205 °C 2.2: 7- percent H2SO4 / 8 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 7 p. 1153 - 1160
反应条件
hydrogenchloride 0.5 h; Heatingacid hydrolysis;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 32, # 3 p. 177 - 183
反应条件
hydrogenchloride multistep reaction: biotransformation, acid hydrolysis;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 32, # 3 p. 177 - 183
反应条件
hydrogenchloride multistep reaction: acid hydrolysis, photolysis;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 32, # 3 p. 177 - 183
