1-溴-3-甲氧基-5-甲苯合成路线 （共 31 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetic acid T=0°C; 0.5 h; 2: With hypophosphorous ether in water; acetic acid T=0 - 20°C;
参考文献
GILEAD SCIENCES, INC.; KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2009/5674 A2, 2009 ;
Location in patent: Page/Page column 423 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 24 h; SolventTemperatureTime;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; GINN, John; LOWE, Michael D.; SARKO, Christopher Ronald; TASBER, Edward S.; ZHANG, Zhonghua
Patent: US2014/73629 A1, 2014 ;
Location in patent: Paragraph 0297; 0313 ;
反应条件
1: 1,3-dibromo-5-methoxybenzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.25 h; 2: methyl iodide in tetrahydrofuran T=-20°C; 2 h;
参考文献
WO2008/43567 A1, ;
Page/Page column 32-33 ;
反应条件
sodium hydroxide; dimethyl sulfate in water
反应条件
potassium carbonate in acetone 4 h; Heating;
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1613 - 1620
反应条件
hypophosphorous acid
参考文献
WO2007/147251 A1, ;
Page/Page column 51-52 ;
反应条件
1.1: 80 percent / Br2; AcOH / methanol / 2 h 2.1: NaNO2; AcOH; aq. HCl / 0.5 h 2.2: 80 percent / 50percent aq. H3PO2 / 8 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 12 p. 1866 - 1882
反应条件
1: 83 percent / aluminium chloride / benzene / 0.5 h / Heating 2: 99 percent / potassium carbonate / acetone / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
反应条件
1: 77 percent / bromine, aluminium powder 2: 83 percent / aluminium chloride / benzene / 0.5 h / Heating 3: 99 percent / potassium carbonate / acetone / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
反应条件
1: NaNH2 2: (i) aq. NaNO2, aq. HBr, (ii) CuBr View Scheme
参考文献
US3671636 , ;
Chem.Abstr., , vol. 77, # 88083
