N-(2-羟乙基)-吡咯烷合成路线 （共 33 条）
反应条件
thionyl chloride 1 h; Heating / reflux;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2007/56170 A2, 2007 ;
Location in patent: Page/Page column 108 ;
WO 2007/056170 A2
反应条件
5A molecular sieve; Novozym 435 (Candida antarctica lipase, EC 3.1.1.3) in toluene T=20°C; Enzymatic reaction; Title compound not separated from byproducts.;
参考文献
Cantele, Francesca; Restelli, Angelo; Riva, Sergio; Tentorio, Dario; Villa, Marco
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 6-7 p. 721 - 725
反应条件
sodium hydroxide; adogen 464 in tetrahydrofuran 6 h; Heating;
参考文献
Moore,G.G.; Hansen,J.C.
Journal of Fluorine Chemistry, 1986 , vol. 32, p. 41
反应条件
hydrogen fluoride T=7 - 8°C; Fluorination; 9.51667 h; Electrochemical reaction;
参考文献
Abe, Takashi; Fukaya, Haruhiko; Hayashi, Eiji; Ono, Taizo; Nishida, Masakazu; Soloshonok, Irina; Okuhara, Kunio
Journal of Fluorine Chemistry, 1999 , vol. 97, # 1-2 p. 229 - 237
反应条件
1: potassium carbonate View Scheme
参考文献
Wright et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3098
反应条件
hydrogenchloride
1) toluene, 3 h, reflux, 2) ether; Yield given. Multistep reaction;
参考文献
Cizmarik; Borovansky; Svec
Pharmazie, 1986 , vol. 41, # 1 p. 58 - 58
参考文献
Parke, Davis and Co.
Patent: US2454092 , 1947 ;
反应条件
toluene-4-sulfonic acid; toluene
参考文献
Schi-Wa Chem.-Pharm. Fabr.
Patent: DE838291 , 1951 ;
DRP/DRBP Org.Chem.
反应条件
1: 2-hydroxybenzoic acid methyl ester With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; 1 h;
2: N-(2-hydroxyethyl)-pyrrolidine in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/77428 A1, 2006 ;
Location in patent: Page/Page column 133 ;
WO 2006/077428 A1
反应条件
1: 2-hydroxybenzoic acid methyl ester With bis(1-methylethyl) ester diazenedicarboxylic acid; triphenylphosphine in tetrahydrofuran
T=20°C; 1 h;
2: N-(2-hydroxyethyl)-pyrrolidine T=20°C; 1.5 h;
参考文献
ASTEX TECHNOLOGY LIMITED
Patent: WO2005/12256 A1, 2005 ;
Location in patent: Page/Page column 146-147 ;
WO 2005/012256 A1
