2-(反式-4-氨基环己基)乙酸合成路线 （共 9 条）
反应条件
sodium hydroxide; hydrogen; nickel in water T=125 - 130°C; P=86258.6 - 97509.8 Torr; 168 h;
参考文献
Shonberg, Jeremy; Herenbrink, Carmen Klein; Lopez, Laura; Christopoulos, Arthur; Scammells, Peter J.; Capuano, Ben; Lane, J. Robert
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9199 - 9221
反应条件
1: H2 / PtO2 / acetic acid 2: aq. H2SO4 View Scheme
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
反应条件
water 12 h; Heating;
参考文献
Karpavichyus, K. I.; Palaima, A. I.; Knunyants, I. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, p. 1689 - 1694
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 10 p. 2374 - 2379
反应条件
1: hydrogenchloride / water / 2 h / |Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: dichloromethane / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 22 p. 9199 - 9221
反应条件
hydrogenchloride in water
pH=5;
参考文献
Gobbi, Luca; Jaeschke, Georg; Rodriguez Sarmiento, Rosa Maria; Steward, Lucinda
Patent: US2009/42943 A1, 2009 ;
Location in patent: Page/Page column 10 ;
US 20090042943 A1
反应条件
1: hydrogenchloride / water / 2 h / |Reflux
2: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
Shonberg, Jeremy; Herenbrink, Carmen Klein; Lopez, Laura; Christopoulos, Arthur; Scammells, Peter J.; Capuano, Ben; Lane, J. Robert
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9199 - 9221
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
反应条件
1: aq. NaOH
2: NaNO2, HCO2H / formic acid
View Scheme
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
