1,4,8,11-四氮杂环十四烷合成路线 （共 60 条）
反应条件
1: With sulfuric acid T=100°C; 48 h; 2: With sodium hydroxide in water
参考文献
Beijing Molecule Science and Technology Co., Ltd.
Patent: EP2163553 A1, 2010 ;
Location in patent: Page/Page column 18-19 ;
反应条件
hydrogenchloride in water T=70°C; 2 h;
参考文献
Tripier, Raphael; Chuburu, Francoise; Le Baccon, Michel; Handel, Henri
Tetrahedron, 2003 , vol. 59, # 25 p. 4573 - 4579
反应条件
1: 90 percent / ethanol / 3 h / 0 °C 2: 75 percent / cesium carbonate / acetonitrile / 18 h / 20 °C 3: hydrochloric acid / H2O / 6 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 21 p. 3271 - 3282
反应条件
ammonia; sodium in tetrahydrofuran T=-33°C; 2 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 33, # 38 p. 5505 - 5508
反应条件
1: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating 2: 63 percent / sulfuric acid, (conc.) / 39 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, , vol. 24, # 8 p. 1731 - 1742
反应条件
1: 50 percent / K2CO3 / acetonitrile / 72 h / 20 °C 2: 70 percent / HCl / H2O / 2 h / 70 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 25 p. 4573 - 4579
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 110 °C 2: sodium, liquid ammonia / tetrahydrofuran / 2 h / -33 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 38 p. 5505 - 5508
反应条件
hydrogenchloride T=70°C;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 71, # 3 p. 337 - 367
反应条件
1: 91 percent / sodium hydroxide / H2O / 1.) 1 hr., 5 deg C, 2.) r.t., 3 hrs. 2: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating 3: 63 percent / sulfuric acid, (conc.) / 39 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, , vol. 24, # 8 p. 1731 - 1742
反应条件
1: 78.3 percent / K2CO3 / dimethylformamide / 8 h / 110 °C 2: 35 percent / 96percent aq. H2SO4 / 50 h / 110 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 73, # 5 p. 685 - 695
