(4-(吡啶-2-基)苯基)甲胺合成路线 (共 4 条)
反应条件
borane-THF in tetrahydrofuran
12 h; Heating / reflux;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22561 A1, 2004 ;
Location in patent: Page 98-99 ;
WO 2004/022561 A1
反应条件
palladium 10 on activated carbon; hydrogen in ethanol
T=20°C; P=3800.26 Torr; 18 h; Large scale reaction;
参考文献
Oumata, Nassima; Ferandin, Yoan; Meijer, Laurent; Galons, Herve
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 641 - 644
反应条件
1: Pd(OAc)2; Ph3P; K2CO3 / tetrahydrofuran
2: NH3; H2 / RaNi / methanol
View Scheme
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Ng, Christina; Murphy, Kathy L.; Ransom, Richard W.; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M.; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3925 - 3929
反应条件
1: Pd(OAc)2; Ph3P; K2CO3 / tetrahydrofuran
2: NH3; H2 / RaNi / methanol
View Scheme
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Ng, Christina; Murphy, Kathy L.; Ransom, Richard W.; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M.; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3925 - 3929