2-氨基-5-甲基苯甲酸合成路线 （共 102 条）
反应条件
acetic acid in 1,4-dioxane; methanol; mineral oil
参考文献
Aventis Pharma Deutschland GmbH
Patent: US6281227 B1, 2001 ;
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
in 2-methoxy-ethanol 1 h; Heating;
参考文献
Stevenson, Thomas M.; Kazmierczak, Franciszek; Leonard, Nelson J.
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 616 - 620
反应条件
1: 76.8 percent / aq. HCl / 0.25 h 2: 35 percent / 1,3-dibromo-5,5-dimethylhydantoin / CCl4; CHCl3 / Heating; Irradiation 3: 87 percent / MgO / N,N-dimethyl-acetamide / 18 h / 90 - 100 °C View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 76.8 percent / aq. HCl / 0.25 h 3: 50 percent / 2,4-dibromo-5,5-dimethylhydantoin / benzoyl peroxide / CCl4; CHCl3 / 18 h / Heating; Irradiation 4: 67 percent / MgO / N,N-dimethyl-acetamide / 16 h / 90 - 100 °C View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 77 percent / dimethylformamide / Heating 2: 100 percent / p-toluene-sulfonic acid / dioxane / 4 h / Heating View Scheme
参考文献
Gupton, John T.; Miller, John F.; Bryant, Robert D.; Maloney, Patrick R.; Foster, Bruce S.
Tetrahedron, 1987 , vol. 43, # 8 p. 1747 - 1752
反应条件
pyridine
Acylation; cyclization; condensation; 0.5 h;
参考文献
Osborne, Alan G.; Goolamali, Zia
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2000 , vol. 56, # 6 p. 1079 - 1100
反应条件
1: pyridine / Ambient temperature
2: acetic anhydride / Heating
View Scheme
参考文献
Fenton; Newton; Wyman; Bagge; Dron; Riddell; Jones
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 265 - 272
反应条件
0.233333 h; Microwave irradiation;
参考文献
Plescia, Salvatore; Raffa, Demetrio; Plescia, Fabiana; Casula, Giovanni; Maggio, Benedetta; Daidone, Giuseppe; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Bombieri, Gabriella; Meneghetti, Fiorella
Arkivoc, 2010 , vol. 2010, # 10 p. 163 - 177
反应条件
1: 97 percent / Br2 / acetic acid / 3 h / 20 °C
2: 100 percent / toluene / 60 °C
View Scheme
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
